MolNFT v1 · #7582 · protein + DNA
Solution structure of the specific DNA complex of the zinc containing DNA binding domain of the erythroid transcription factor gata-1 by multidimensional NMR
1GAU · DNA (5'-D(P*AP*GP*AP*TP*AP*AP*AP*C)-3'): “Solution structure of the specific DNA complex of the zinc containing DNA binding domain of the erythroid…”. Solution nmr, 1 pocket (best druggability 0.61). MolNFT v1 #7582 on GenesisL1: 3D…
- PDB
- 1GAU
- Type
- protein + DNA
- Length
- 76 residues
- Chains
- 3
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA (5'-D(P*AP*GP*AP*TP*AP*AP*AP*C)-3'); DNA (5'-D(P*GP*TP*TP*TP*AP*TP*CP*T)-3')…
- UniProt
- P17678
- Pockets
- 1 · best druggability 0.61
Structure
solution nmr · 3 distinct chains · 17% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | DNA (5'-D(P*AP*GP*AP*TP*AP*AP*AP*C)-3') | dna | 8 | — | — |
| C | DNA (5'-D(P*GP*TP*TP*TP*AP*TP*CP*T)-3') | dna | 8 | — | — |
| A | Erythroid transcription factor gata-1 | protein | 60 | 17% helix, 13% strand | P17678 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 174 | 0.61 | 0.84 | 18 | empty |
Interfaces
3 interfaces between chains.
- C–A · 649 Ų buried · 13 hydrogen bonds · protein-nucleic
- B–A · 335 Ų buried · 7 hydrogen bonds · protein-nucleic
- B–C · 333 Ų buried · 28 hydrogen bonds · nucleic-nucleic
Compared structures
- 1GAU · Solution structure of the specific DNA complex of the zinc containing DNA binding domain… · the same entry in another collection · chain B against B, TM-score 1.00
- P17678 · AlphaFold monomer V2.0 prediction for erythroid transcription factor (P17678) · a predicted model of the same protein · chain A against A, TM-score 0.72
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P17678
- Elsewhere: RCSB PDB 1GAU · PDBe 1GAU · UniProt P17678
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