MolNFT v1 · #75789 · protein + RNA

Crystal structure of the pumilio-homology domain from human PUMILIO2 in complex with ERK2 nre

3Q0S · Pumilio homolog 2: “Crystal structure of the pumilio-homology domain from human PUMILIO2 in complex with ERK2 nre”. X-ray diffraction, 1 pocket (best druggability 0.30). MolNFT v1 #75789 on GenesisL1: 3D structure, binding sites and…

PDB: 3Q0S
Type: protein + RNA
Length: 351 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pumilio homolog 2; 5'-R(UP*GP*UP*AP*CP*AP*UP*C)-3'
UniProt: Q8TB72
Pockets: 1 · best druggability 0.30

Structure

x-ray diffraction · 2 distinct chains · 68% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pumilio homolog 2	protein	343	68% helix, 0% strand	Q8TB72
B	5'-R(UPGPUPAPCPAPUP*C)-3'	rna	8	—	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	50	0.30	0.76	15	empty

Interfaces

1 interface between chains.

A–B · 1239 Å² buried · 32 hydrogen bonds · protein-nucleic

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

3Q0S · Crystal structure of the PUMILIO-homology domain from Human PUMILIO2 in complex with erk2… · the same entry in another collection · chain B against B, TM-score 1.00
Q8TB72 · AlphaFold monomer V2.0 prediction for pumilio homolog 2 (Q8TB72) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8TB72
Elsewhere: RCSB PDB 3Q0S · PDBe 3Q0S · UniProt Q8TB72

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.