MolNFT v1 · #75786 · protein + RNA

Crystal structure of the pumilio-homology domain from human PUMILIO1 in complex with hunchback nre

3Q0P · Pumilio homolog 1: “Crystal structure of the pumilio-homology domain from human PUMILIO1 in complex with hunchback nre”. X-ray diffraction, 1 ligand (CL). MolNFT v1 #75786 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 3Q0P
Type: protein + RNA
Length: 697 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pumilio homolog 1; 5'-R(UP*GP*UP*AP*UP*AP*UP*A)-3'
UniProt: Q14671
Ligands: CL

Structure

x-ray diffraction · 3 distinct chains · 73% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pumilio homolog 1	protein	341	73% helix, 1% strand	Q14671
B	Pumilio homolog 1	protein	340	73% helix, 1% strand	Q14671
C, D	5'-R(UPGPUPAPUPAPUP*A)-3'	rna	8	—	—

Ligands and binding sites

CL · Chloride ion · ion · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

2 interfaces between chains.

A–C · 1323 Å² buried · 44 hydrogen bonds · protein-nucleic
B–D · 1309 Å² buried · 41 hydrogen bonds · protein-nucleic

Compared structures

3Q0P · Crystal structure of the PUMILIO-homology domain from Human PUMILIO1 in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
Q14671 · AlphaFold monomer V2.0 prediction for pumilio homolog 1 (Q14671) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q14671
Elsewhere: RCSB PDB 3Q0P · PDBe 3Q0P · UniProt Q14671

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