MolNFT v1 · #75739 · protein
Structure of the myosin X MYTH4-FERM/DCC complex
3PZD · Myosin-X: “Structure of the myosin X MYTH4-FERM/DCC complex”. X-ray diffraction, 4 pockets (best druggability 0.77). MolNFT v1 #75739 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3PZD
- Type
- protein
- Length
- 534 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin-X; Netrin receptor dcc
- UniProt
- Q9HD67, P70211
- Pockets
- 4 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 49% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Myosin-X | protein | 498 | 47% helix, 14% strand | Q9HD67 |
| B | Netrin receptor dcc | protein | 36 | 69% helix, 0% strand | P70211 |
Ligands and binding sites
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 876 | 0.77 | 0.80 | 105 | empty |
| 2 | 63 | 0.40 | 0.80 | 19 | empty |
| 3 | 80 | 0.30 | 0.73 | 19 | empty |
| 4 | 61 | 0.28 | 0.74 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 849 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 3PZD · Structure of the myosin X MyTH4-FERM/DCC complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q9HD67 · AlphaFold monomer V2.0 prediction for unconventional myosin-X (Q9HD67) · a predicted model of the same protein · chain A against A, TM-score 0.95
- P70211 · AlphaFold monomer V2.0 prediction for netrin receptor dcc (P70211) · a predicted model of the same protein · chain B against A, TM-score 0.47
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HD67
- Every structure of UniProt P70211
- Elsewhere: RCSB PDB 3PZD · PDBe 3PZD · UniProt Q9HD67 · UniProt P70211
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