MolNFT v1 · #75657 · protein
An immmunodominant ctl epitope from rinderpest virus presented by cattle MHC class I molecule N*01801(BOLA-A11)
3PWU · MHC class I antigen: “An immmunodominant ctl epitope from rinderpest virus presented by cattle MHC class I molecule…”. X-ray diffraction, 3 pockets (best druggability 0.67). MolNFT v1 #75657 on GenesisL1: 3D structure, binding sites…
- PDB
- 3PWU
- Type
- protein
- Length
- 382 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MHC class I antigen; Beta-2-microglobulin; Ipa from hemagglutinin glycoprotein
- UniProt
- Q95477, P01887, P41355
- Pockets
- 3 · best druggability 0.67
Structure
x-ray diffraction · 3 distinct chains · 19% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MHC class I antigen | protein | 274 | 27% helix, 39% strand | Q95477 |
| B | Beta-2-microglobulin | protein | 99 | 0% helix, 49% strand | P01887 |
| C | Ipa from hemagglutinin glycoprotein | protein | 9 | 0% helix, 0% strand | P41355 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 566 | 0.67 | 0.77 | 52 | empty |
| 2 | 154 | 0.49 | 0.78 | 34 | empty |
| 3 | 56 | 0.32 | 0.77 | 15 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1311 Ų buried · 23 hydrogen bonds · protein-protein
- A–C · 880 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 3PWU · An immmunodominant CTL epitope from rinderpest virus presented by cattle MHC class I… · the same entry in another collection · chain A against A, TM-score 1.00
- P01887 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (P01887) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q95477
- Every structure of UniProt P01887
- Every structure of UniProt P41355
- Elsewhere: RCSB PDB 3PWU · PDBe 3PWU · UniProt Q95477 · UniProt P01887 · UniProt P41355
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