MolNFT v1 · #75593 · protein
Crystal structure of a pre-translocation state mbp-maltose transporter complex bound to AMP-pnp
3PUZ · Maltose transporter subunit: “Crystal structure of a pre-translocation state mbp-maltose transporter complex bound to AMP-pnp”. X-ray diffraction, 4 ligands (ANP, PGV, GLC), 20 pockets (best druggability 0.87). MolNFT v1 #75593 on…
- PDB
- 3PUZ
- Type
- protein
- Length
- 1,873 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Maltose transporter subunit; Fused maltose transport subunit, ATP-binding component of…
- UniProt
- B1XC33, B1XC32, B1XC31, B1XC34
- Ligands
- ANP, PGV, GLC, MG
- Pockets
- 20 · best druggability 0.87
Structure
x-ray diffraction · 4 distinct chains · 46% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E | Maltose transporter subunit | protein | 370 | 44% helix, 18% strand | B1XC33 |
| F | Maltose transporter subunit | protein | 481 | 51% helix, 15% strand | B1XC32 |
| G | Maltose transporter subunit | protein | 282 | 66% helix, 2% strand | B1XC31 |
| A, B | Fused maltose transport subunit, ATP-binding component of ABC superfamily | protein | 370 | 25% helix, 34% strand | B1XC34 |
Ligands and binding sites
- ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · 2 copies · chains A, B
- PGV · (1R)-2-{[{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl (11E)-octadec-11-enoate · ligand · chains F, G
- GLC · alpha-D-glucopyranose · sugar · 4 copies · chains E, G, F
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 722 | 0.87 | 0.90 | 90 | empty |
| 2 | 1182 | 0.85 | 0.86 | 91 | GLC |
| 3 | 932 | 0.81 | 0.83 | 93 | empty |
| 4 | 208 | 0.79 | 0.93 | 29 | GLC |
| 5 | 509 | 0.77 | 0.84 | 62 | empty |
Interfaces
7 interfaces between chains.
- F–G · 3870 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 1854 Ų buried · 18 hydrogen bonds · protein-protein
- E–F · 1700 Ų buried · 16 hydrogen bonds · protein-protein
- E–G · 1073 Ų buried · 9 hydrogen bonds · protein-protein
- F–B · 790 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 3PUZ · Crystal Structure of a pre-translocation state MBP-Maltose transporter complex bound to… · the same entry in another collection · chain E against E, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B1XC33
- Every structure of UniProt B1XC32
- Every structure of UniProt B1XC31
- Every structure of UniProt B1XC34
- Elsewhere: RCSB PDB 3PUZ · PDBe 3PUZ · UniProt B1XC33 · UniProt B1XC32 · UniProt B1XC31 · UniProt B1XC34
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.