MolNFT v1 · #75541 · protein
Phosphatidylinositol-specific phospholipase C mutant D274S
3PTD: “Phosphatidylinositol-specific phospholipase C mutant D274S”. X-ray diffraction, 1 pocket (best druggability 0.45). MolNFT v1 #75541 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3PTD
- Type
- protein
- Length
- 296 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphatidylinositol-specific phospholipase C
- EC
- 3.1.4.10
- UniProt
- P14262
- Pockets
- 1 · best druggability 0.45
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphatidylinositol-specific phospholipase C (EC 3.1.4.10) | protein | 296 | 31% helix, 21% strand | P14262 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 134 | 0.45 | 0.77 | 23 | empty |
Compared structures
- 3PTD · Phosphatidylinositol-specific phospholipase C mutant D274S · the same entry in another collection · chain A against A, TM-score 1.00
- P14262 · AlphaFold monomer V2.0 prediction for 1-phosphatidylinositol phosphodiesterase (P14262) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14262
- Elsewhere: RCSB PDB 3PTD · PDBe 3PTD · UniProt P14262
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