MolNFT v1 · #75533 · protein
Crystal structure of the C-terminal lobe of the human UBR5 hect domain
3PT3 · E3 ubiquitin-protein ligase UBR5: “Crystal structure of the C-terminal lobe of the human UBR5 hect domain”. X-ray diffraction, 1 pocket (best druggability 0.41). MolNFT v1 #75533 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 3PT3
- Type
- protein
- Length
- 185 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- E3 ubiquitin-protein ligase UBR5
- EC
- 6.3.2.-
- UniProt
- O95071
- Pockets
- 1 · best druggability 0.41
Structure
x-ray diffraction · 2 distinct chains · 50% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase UBR5 (EC 6.3.2.-) | protein | 88 | 47% helix, 19% strand | O95071 |
| B | E3 ubiquitin-protein ligase UBR5 (EC 6.3.2.-) | protein | 97 | 53% helix, 18% strand | O95071 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 98 | 0.41 | 0.77 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 288 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 3PT3 · Crystal structure of the C-terminal lobe of the human UBR5 HECT domain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95071
- Elsewhere: RCSB PDB 3PT3 · PDBe 3PT3 · UniProt O95071
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