MolNFT v1 · #75513 · protein

Crystal structure of the SPT6 core domain from saccharomyces cerevisiae, form SPT6(239-1451)

3PSI · Transcription elongation factor SPT6: “Crystal structure of the SPT6 core domain from saccharomyces cerevisiae, form SPT6(239-1451)”. X-ray diffraction, 13 pockets (best druggability 0.64). MolNFT v1 #75513 on GenesisL1: 3D…

PDB: 3PSI
Type: protein
Length: 843 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcription elongation factor SPT6
UniProt: P23615
Pockets: 13 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 53% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcription elongation factor SPT6	protein	843	53% helix, 9% strand	P23615

Pockets

13 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	507	0.64	0.76	49	empty
2	306	0.61	0.79	33	empty
3	226	0.57	0.79	27	empty
4	239	0.48	0.74	31	empty
5	61	0.47	0.83	17	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

3PSI · Crystal Structure of the Spt6 core domain from Saccharomyces cerevisiae, Form… · the same entry in another collection · chain A against A, TM-score 1.00
P23615 · AlphaFold monomer V2.0 prediction for transcription elongation factor SPT6 (P23615) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P23615
Elsewhere: RCSB PDB 3PSI · PDBe 3PSI · UniProt P23615

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