MolNFT v1 · #7547 · protein
Crystal structure of a complex between E.COLI hprt and imp
1G9S · Hypoxanthine phosphoribosyltransferase: “Crystal structure of a complex between E.COLI hprt and imp”. X-ray diffraction, 2 ligands (IMP, N), 3 pockets (best druggability 0.56). MolNFT v1 #7547 on GenesisL1: 3D structure, binding…
- PDB
- 1G9S
- Type
- protein
- Length
- 338 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hypoxanthine phosphoribosyltransferase
- EC
- 2.4.2.8
- UniProt
- P0A9M2
- Ligands
- IMP, N
- Pockets
- 3 · best druggability 0.56
Structure
x-ray diffraction · 1 distinct chain · 24% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) | protein | 169 | 24% helix, 33% strand | P0A9M2 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 198 | 0.56 | 0.79 | 20 | empty |
| 2 | 274 | 0.55 | 0.76 | 34 | IMP |
| 3 | 238 | 0.54 | 0.77 | 28 | N |
Interfaces
1 interface between chains.
- A–B · 1272 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 1G9S · Crystal structure of a complex between E.COLI hprt and imp · the same entry in another collection · chain A against A, TM-score 1.00
- P0A9M2 · AlphaFold monomer V2.0 prediction for hypoxanthine phosphoribosyltransferase (P0A9M2) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A9M2
- Elsewhere: RCSB PDB 1G9S · PDBe 1G9S · UniProt P0A9M2
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