MolNFT v1 · #75214 · protein
The crystal structure of TP34 bound to co (II) ion at pH 7.5
3PJL · 34 kda membrane antigen: “The crystal structure of TP34 bound to co (II) ion at pH 7.5”. X-ray diffraction, 2 ligands (CO, SO4), 4 pockets (best druggability 0.44). MolNFT v1 #75214 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3PJL
- Type
- protein
- Length
- 314 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 34 kda membrane antigen
- UniProt
- P19478
- Ligands
- CO, SO4
- Pockets
- 4 · best druggability 0.44
Structure
x-ray diffraction · 1 distinct chain · 4% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | 34 kda membrane antigen | protein | 157 | 4% helix, 46% strand | P19478 |
Ligands and binding sites
- CO · Cobalt (II) ion · metal · 7 copies · chains A, B
- SO4 · Sulfate ion · ion · 3 copies · chains A, B
- EDO · 1,2-ethanediol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 150 | 0.44 | 0.75 | 32 | empty |
| 2 | 172 | 0.44 | 0.74 | 33 | empty |
| 3 | 74 | 0.38 | 0.78 | 19 | EDO |
| 4 | 65 | 0.36 | 0.78 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 1721 Ų buried · 30 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19478
- Elsewhere: RCSB PDB 3PJL · PDBe 3PJL · UniProt P19478
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