MolNFT v1 · #75117 · protein

ASP348ARG mutant of ecfadl

3PGR · Long-chain fatty acid transport protein: “ASP348ARG mutant of ecfadl”. X-ray diffraction, 3 pockets (best druggability 0.70). MolNFT v1 #75117 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3PGR
Type: protein
Length: 376 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Long-chain fatty acid transport protein
UniProt: P10384
Pockets: 3 · best druggability 0.70

Structure

x-ray diffraction · 1 distinct chain · 12% helix, 55% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Long-chain fatty acid transport protein	protein	376	12% helix, 55% strand	P10384

Ligands and binding sites

C8E · (hydroxyethyloxy)tri(ethyloxy)octane · additive · 10 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	222	0.70	0.87	43	empty
2	356	0.64	0.78	34	empty
3	401	0.62	0.77	35	empty

Compared structures

3PGR · Asp348Arg mutant of EcFadL · the same entry in another collection · chain A against A, TM-score 1.00
P10384 · AlphaFold monomer V2.0 prediction for long-chain fatty acid transport protein (P10384) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10384
Elsewhere: RCSB PDB 3PGR · PDBe 3PGR · UniProt P10384

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