MolNFT v1 · #75102 · protein
Structural characterization of pseudomonas 7A glutaminase-asparaginase
3PGA: “Structural characterization of pseudomonas 7A glutaminase-asparaginase”. X-ray diffraction, 15 pockets (best druggability 0.87). MolNFT v1 #75102 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3PGA
- Type
- protein
- Length
- 1,318 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutaminase-asparaginase
- EC
- 3.5.1.1
- UniProt
- P10182
- Pockets
- 15 · best druggability 0.87
Structure
x-ray diffraction · 3 distinct chains · 31% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| 1, 2 | Glutaminase-asparaginase (EC 3.5.1.1) | protein | 330 | 31% helix, 23% strand | P10182 |
| 3 | Glutaminase-asparaginase (EC 3.5.1.1) | protein | 329 | 32% helix, 21% strand | P10182 |
| 4 | Glutaminase-asparaginase (EC 3.5.1.1) | protein | 329 | 32% helix, 23% strand | P10182 |
Pockets
15 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1197 | 0.87 | 0.88 | 120 | empty |
| 2 | 123 | 0.77 | 0.97 | 39 | empty |
| 3 | 147 | 0.69 | 0.89 | 47 | empty |
| 4 | 54 | 0.67 | 0.96 | 18 | empty |
| 5 | 124 | 0.63 | 0.87 | 28 | empty |
Interfaces
6 interfaces between chains.
- 2–4 · 2500 Ų buried · 45 hydrogen bonds · protein-protein
- 1–3 · 2490 Ų buried · 41 hydrogen bonds · protein-protein
- 3–4 · 1141 Ų buried · 19 hydrogen bonds · protein-protein
- 2–3 · 1110 Ų buried · 12 hydrogen bonds · protein-protein
- 1–2 · 1108 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 3PGA · Structural characterization of pseudomonas 7A glutaminase-asparaginase · the same entry in another collection · chain 4 against 4, TM-score 1.00
- P10182 · AlphaFold monomer V2.0 prediction for glutaminase-asparaginase (P10182) · a predicted model of the same protein · chain 3 against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10182
- Elsewhere: RCSB PDB 3PGA · PDBe 3PGA · UniProt P10182
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