MolNFT v1 · #75022 · protein

Crystal structural of mouse tyrosine aminotransferase

3PDX: “Crystal structural of mouse tyrosine aminotransferase”. X-ray diffraction, 3 pockets (best druggability 0.57). MolNFT v1 #75022 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3PDX
Type: protein
Length: 379 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosine aminotransferase
EC: 2.6.1.5
UniProt: Q8QZR1
Pockets: 3 · best druggability 0.57

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosine aminotransferase (EC 2.6.1.5)	protein	379	41% helix, 15% strand	Q8QZR1

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	87	0.57	0.86	24	empty
2	84	0.32	0.73	17	empty
3	50	0.28	0.74	13	empty

Modifications

Observed in the structure: 1 disulfide, 1 modified (disulfide, cofactor).

Compared structures

3PDX · Crystal structural of mouse tyrosine aminotransferase · the same entry in another collection · chain A against A, TM-score 1.00
Q8QZR1 · AlphaFold monomer V2.0 prediction for tyrosine aminotransferase (Q8QZR1) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8QZR1
Elsewhere: RCSB PDB 3PDX · PDBe 3PDX · UniProt Q8QZR1

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