MolNFT v1 · #74941 · protein

Refined crystal structure of human procathepsin B at 2.5 ångström resolution

3PBH: “Refined crystal structure of human procathepsin B at 2.5 ångström resolution”. X-ray diffraction, 1 pocket (best druggability 0.45). MolNFT v1 #74941 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3PBH
Type: protein
Length: 317 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Procathepsin B
EC: 3.4.22.1
UniProt: P07858
Pockets: 1 · best druggability 0.45

Structure

x-ray diffraction · 1 distinct chain · 26% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Procathepsin B (EC 3.4.22.1)	protein	317	26% helix, 22% strand	P07858

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	59	0.45	0.83	21	empty

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

3PBH · Refined crystal structure of human procathepsin B at 2.5 ångström resolution · the same entry in another collection · chain A against A, TM-score 1.00
P07858 · AlphaFold monomer V2.0 prediction for cathepsin B (P07858) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07858
Elsewhere: RCSB PDB 3PBH · PDBe 3PBH · UniProt P07858

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