MolNFT v1 · #74844 · protein
Crystal structure of polyprenyl synthase from enterococcus faecalis V583
3P8L · Geranyltranstransferase: “Crystal structure of polyprenyl synthase from enterococcus faecalis V583”. X-ray diffraction, 7 pockets (best druggability 0.64). MolNFT v1 #74844 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 3P8L
- Type
- protein
- Length
- 558 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Geranyltranstransferase
- UniProt
- Q836W4
- Pockets
- 7 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 74% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Geranyltranstransferase | protein | 283 | 73% helix, 1% strand | Q836W4 |
| B | Geranyltranstransferase | protein | 275 | 76% helix, 1% strand | Q836W4 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 411 | 0.64 | 0.78 | 45 | empty |
| 2 | 380 | 0.63 | 0.78 | 44 | empty |
| 3 | 100 | 0.38 | 0.75 | 18 | empty |
| 4 | 53 | 0.35 | 0.79 | 13 | empty |
| 5 | 52 | 0.32 | 0.77 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 2108 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 3P8L · Crystal structure of polyprenyl synthase from Enterococcus faecalis V583 · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q836W4
- Elsewhere: RCSB PDB 3P8L · PDBe 3P8L · UniProt Q836W4
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