MolNFT v1 · #74811 · protein
Rat insulin degrading enzyme (insulysin) E111F mutant with two bound peptides
3P7O · Insulin-degrading enzyme: “Rat insulin degrading enzyme (insulysin) E111F mutant with two bound peptides”. X-ray diffraction, 18 pockets (best druggability 0.81). MolNFT v1 #74811 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3P7O
- Type
- protein
- Length
- 973 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin-degrading enzyme; Active site bound peptide; Distal site bound peptide
- EC
- 3.4.24.56
- UniProt
- P35559
- Pockets
- 18 · best druggability 0.81
Structure
x-ray diffraction · 3 distinct chains · 42% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Insulin-degrading enzyme (EC 3.4.24.56) | protein | 958 | 42% helix, 21% strand | P35559 |
| B | Active site bound peptide | protein | 8 | 0% helix, 13% strand | — |
| C | Distal site bound peptide | protein | 7 | 0% helix, 14% strand | — |
Pockets
18 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1135 | 0.81 | 0.82 | 108 | empty |
| 2 | 492 | 0.73 | 0.82 | 63 | empty |
| 3 | 179 | 0.57 | 0.81 | 25 | empty |
| 4 | 222 | 0.55 | 0.78 | 26 | empty |
| 5 | 204 | 0.53 | 0.78 | 34 | empty |
Interfaces
3 interfaces between chains.
- A–B · 500 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 311 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 40 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3P7O · Rat Insulin Degrading Enzyme (Insulysin) E111F mutant with two bound peptides · the same entry in another collection · chain A against A, TM-score 1.00
- P35559 · AlphaFold monomer V2.0 prediction for insulin-degrading enzyme (P35559) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35559
- Elsewhere: RCSB PDB 3P7O · PDBe 3P7O · UniProt P35559
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