MolNFT v1 · #7469 · protein
Crystal structure of dsred, a red fluorescent protein from discosoma sp. red
1G7K · Fluorescent protein FP583: “Crystal structure of dsred, a red fluorescent protein from discosoma sp. red”. X-ray diffraction, 1 ligand (CRQ), 13 pockets (best druggability 0.83). MolNFT v1 #7469 on GenesisL1: 3D structure, binding…
- PDB
- 1G7K
- Type
- protein
- Length
- 868 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fluorescent protein FP583
- UniProt
- Q9U6Y8
- Ligands
- CRQ
- Pockets
- 13 · best druggability 0.83
Structure
x-ray diffraction · 1 distinct chain · 6% helix, 57% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Fluorescent protein FP583 | protein | 217 | 6% helix, 57% strand | Q9U6Y8 |
Ligands and binding sites
- CRQ · [2-(3-carbamoyl-1-imino-propyl)-4-(4-hydroxy-benzylidene)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1014 | 0.83 | 0.84 | 96 | empty |
| 2 | 88 | 0.75 | 0.97 | 30 | CRQ |
| 3 | 85 | 0.74 | 0.97 | 29 | CRQ |
| 4 | 75 | 0.72 | 0.97 | 29 | CRQ |
| 5 | 77 | 0.70 | 0.95 | 29 | CRQ |
Interfaces
4 interfaces between chains.
- A–C · 1366 Ų buried · 17 hydrogen bonds · protein-protein
- B–D · 1344 Ų buried · 20 hydrogen bonds · protein-protein
- C–D · 1104 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 1071 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 24 modified, 8 cofactor (engineered, chromophore).
Compared structures
- 1G7K · Crystal structure of dsred, a red fluorescent protein from discosoma sp. red · the same entry in another collection · chain B against B, TM-score 1.00
- Q9U6Y8 · AlphaFold monomer V2.0 prediction for red fluorescent protein DRFP583 (Q9U6Y8) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9U6Y8
- Elsewhere: RCSB PDB 1G7K · PDBe 1G7K · UniProt Q9U6Y8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.