MolNFT v1 · #74673 · protein
Human transthyretin (ttr) complexed with (Z)-5-(3,5-dibromo-4- hydroxybenzylidene)-imino-1-methylimidazolidin-4-one
3P3S: “Human transthyretin (ttr) complexed with (Z)-5-(3,5-dibromo-4…”. X-ray diffraction, 1 ligand (3M2). MolNFT v1 #74673 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3P3S
- Type
- protein
- Length
- 230 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transthyretin
- UniProt
- P02766
- Ligands
- 3M2
Structure
x-ray diffraction · 1 distinct chain · 6% helix, 53% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Transthyretin | protein | 115 | 6% helix, 53% strand | P02766 |
Ligands and binding sites
- 3M2 · (5Z)-2-amino-5-(3,5-dibromo-4-hydroxybenzylidene)-1-methyl-1,5-dihydro-4H-imidazol-4-one · ligand · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 942 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 3P3S · Human transthyretin (TTR) complexed with (Z)-5-(3,5-dibromo-4-hydroxybenzylidene)-imino-1… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02766
- Elsewhere: RCSB PDB 3P3S · PDBe 3P3S · UniProt P02766
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