MolNFT v1 · #74521 · protein
Crystal structure of MAPK from cryptosporidium parvum, CGD2_1960
3OZ6 · Mitogen-activated protein kinase 1, SERINE/THREONINE…: “Crystal structure of MAPK from cryptosporidium parvum, CGD2_1960”. X-ray diffraction, 6 pockets (best druggability 0.63). MolNFT v1 #74521 on GenesisL1: 3D structure, binding…
- PDB
- 3OZ6
- Type
- protein
- Length
- 684 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitogen-activated protein kinase 1, SERINE/THREONINE protein kinase
- UniProt
- A3FQ79
- Pockets
- 6 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitogen-activated protein kinase 1, SERINE/THREONINE protein kinase | protein | 343 | 45% helix, 13% strand | A3FQ79 |
| B | Mitogen-activated protein kinase 1, SERINE/THREONINE protein kinase | protein | 341 | 46% helix, 13% strand | A3FQ79 |
Ligands and binding sites
- GOL · Glycerol · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 383 | 0.63 | 0.78 | 54 | GOL |
| 2 | 328 | 0.61 | 0.78 | 34 | empty |
| 3 | 60 | 0.59 | 0.91 | 16 | empty |
| 4 | 70 | 0.45 | 0.82 | 13 | empty |
| 5 | 113 | 0.42 | 0.76 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 625 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 3OZ6 · Crystal structure of MapK from Cryptosporidium Parvum, cgd2_1960 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A3FQ79
- Elsewhere: RCSB PDB 3OZ6 · PDBe 3OZ6 · UniProt A3FQ79
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