MolNFT v1 · #7448 · protein
Crystal structure of the globular region of the prion protein URE2 from yeast saccharomyces cerevisiae
1G6Y · URE2 protein: “Crystal structure of the globular region of the prion protein URE2 from yeast saccharomyces cerevisiae”. X-ray diffraction, 7 pockets (best druggability 0.73). MolNFT v1 #7448 on GenesisL1: 3D structure, binding sites…
- PDB
- 1G6Y
- Type
- protein
- Length
- 502 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- URE2 protein
- UniProt
- P23202
- Pockets
- 7 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 57% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | URE2 protein | protein | 245 | 54% helix, 8% strand | P23202 |
| B | URE2 protein | protein | 257 | 60% helix, 7% strand | P23202 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 543 | 0.73 | 0.81 | 39 | empty |
| 2 | 514 | 0.71 | 0.80 | 38 | empty |
| 3 | 206 | 0.54 | 0.78 | 25 | empty |
| 4 | 132 | 0.42 | 0.75 | 27 | empty |
| 5 | 144 | 0.41 | 0.74 | 28 | empty |
Interfaces
1 interface between chains.
- A–B · 1888 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 1G6Y · Crystal structure of the globular region of the prion protein URE2 from yeast… · the same entry in another collection · chain A against A, TM-score 1.00
- P23202 · AlphaFold monomer V2.0 prediction for transcriptional regulator URE2 (P23202) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23202
- Elsewhere: RCSB PDB 1G6Y · PDBe 1G6Y · UniProt P23202
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