MolNFT v1 · #7445 · protein
Complex of the camelid heavy-chain antibody fragment cab- CA05 with bovine carbonic anhydrase
1G6V: “Complex of the camelid heavy-chain antibody fragment cab- CA05 with bovine carbonic anhydrase”. X-ray diffraction, 1 ligand (ZN), 2 pockets (best druggability 0.52). MolNFT v1 #7445 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1G6V
- Type
- protein
- Length
- 382 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Carbonic anhydrase; Antibody heavy chain
- EC
- 4.2.1.1
- UniProt
- P00921
- Ligands
- ZN
- Pockets
- 2 · best druggability 0.52
Structure
x-ray diffraction · 2 distinct chains · 12% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Carbonic anhydrase (EC 4.2.1.1) | protein | 256 | 13% helix, 30% strand | P00921 |
| K | Antibody heavy chain | protein | 126 | 8% helix, 50% strand | — |
Ligands and binding sites
- ZN · Zinc ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 147 | 0.52 | 0.80 | 21 | ZN |
| 2 | 55 | 0.44 | 0.84 | 15 | empty |
Interfaces
1 interface between chains.
- A–K · 606 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 1G6V · Complex of the camelid heavy-chain antibody fragment CAB-CA05 with bovine carbonic… · the same entry in another collection · chain A against A, TM-score 1.00
- P00921 · AlphaFold monomer V2.0 prediction for carbonic anhydrase 2 (P00921) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00921
- Elsewhere: RCSB PDB 1G6V · PDBe 1G6V · UniProt P00921
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.