MolNFT v1 · #74369 · protein

Structure of the nucleoprotein from rift valley fever virus

3OUO: “Structure of the nucleoprotein from rift valley fever virus”. X-ray diffraction, 1 ligand (NO2), 4 pockets (best druggability 0.78). MolNFT v1 #74369 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3OUO
Type: protein
Length: 731 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nucleoprotein
UniProt: P21700
Ligands: NO2
Pockets: 4 · best druggability 0.78

Structure

x-ray diffraction · 2 distinct chains · 69% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Nucleoprotein	protein	244	69% helix, 1% strand	P21700
C	Nucleoprotein	protein	243	68% helix, 1% strand	P21700

Ligands and binding sites

NO2 · Nitrite ion · ion · 3 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1038	0.78	0.80	107	NO2
2	976	0.73	0.76	91	NO2
3	447	0.66	0.78	38	empty
4	96	0.38	0.76	18	empty

Interfaces

2 interfaces between chains.

A–B · 1878 Å² buried · 26 hydrogen bonds · protein-protein
A–C · 265 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 33 modified (engineered).

Compared structures

3OUO · Structure of the Nucleoprotein from Rift Valley Fever Virus · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P21700
Elsewhere: RCSB PDB 3OUO · PDBe 3OUO · UniProt P21700

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