MolNFT v1 · #74215 · protein
Structural basis of type-I interferon sequestration by a poxvirus decoy receptor
3OQ3 · Interferon alpha-5: “Structural basis of type-I interferon sequestration by a poxvirus decoy receptor”. X-ray diffraction, 2 ligands (ZN, CL), 5 pockets (best druggability 0.81). MolNFT v1 #74215 on GenesisL1: 3D structure, binding…
- PDB
- 3OQ3
- Type
- protein
- Length
- 495 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interferon alpha-5; Ifn-ALPHA/BETA binding protein C12R
- UniProt
- P07349, Q9JFS5
- Ligands
- ZN, CL
- Pockets
- 5 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interferon alpha-5 | protein | 166 | 72% helix, 0% strand | P07349 |
| B | Ifn-ALPHA/BETA binding protein C12R | protein | 329 | 12% helix, 45% strand | Q9JFS5 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains A, B
- CL · Chloride ion · ion · chains A, B
- EDO · 1,2-ethanediol · additive · 4 copies · chains A, B
- ACT · Acetate ion · additive · 2 copies · chains A, B
- EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1067 | 0.81 | 0.82 | 93 | empty |
| 2 | 264 | 0.69 | 0.84 | 38 | EDO |
| 3 | 360 | 0.65 | 0.80 | 39 | ZN, CL, ACT |
| 4 | 120 | 0.48 | 0.80 | 23 | empty |
| 5 | 95 | 0.34 | 0.74 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 2755 Ų buried · 35 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 disulfide (disulfide).
Compared structures
- 3OQ3 · Structural Basis of Type-I Interferon Sequestration by a Poxvirus Decoy Receptor · the same entry in another collection · chain A against A, TM-score 1.00
- P07349 · AlphaFold monomer V2.0 prediction for interferon alpha-5 (P07349) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07349
- Every structure of UniProt Q9JFS5
- Elsewhere: RCSB PDB 3OQ3 · PDBe 3OQ3 · UniProt P07349 · UniProt Q9JFS5
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