MolNFT v1 · #74208 · protein

Crystal structure of the RPH1 catalytic core

3OPW · DNA damage-responsive transcriptional repressor RPH1: “Crystal structure of the RPH1 catalytic core”. X-ray diffraction, 3 pockets (best druggability 0.60). MolNFT v1 #74208 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 3OPW
Type: protein
Length: 298 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA damage-responsive transcriptional repressor RPH1
EC: 1.14.11.27
UniProt: P39956
Pockets: 3 · best druggability 0.60

Structure

x-ray diffraction · 1 distinct chain · 27% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA damage-responsive transcriptional repressor RPH1 (EC 1.14.11.27)	protein	298	27% helix, 26% strand	P39956

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	272	0.60	0.79	31	empty
2	80	0.41	0.79	17	empty
3	59	0.29	0.75	14	empty

Compared structures

3OPW · Crystal Structure of the Rph1 catalytic core · the same entry in another collection · chain A against A, TM-score 1.00
P39956 · AlphaFold monomer V2.0 prediction for DNA damage-responsive transcriptional repressor… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P39956
Elsewhere: RCSB PDB 3OPW · PDBe 3OPW · UniProt P39956

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.