MolNFT v1 · #74128 · protein
Yeast ENT3_ENTH-VTI1P_HABC complex structure
3ONL · Epsin-3: “Yeast ENT3_ENTH-VTI1P_HABC complex structure”. X-ray diffraction, 2 pockets (best druggability 0.52). MolNFT v1 #74128 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3ONL
- Type
- protein
- Length
- 371 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Epsin-3; T-snare VTI1
- UniProt
- P47160, Q04338
- Pockets
- 2 · best druggability 0.52
Structure
x-ray diffraction · 3 distinct chains · 79% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Epsin-3 | protein | 140 | 73% helix, 1% strand | P47160 |
| B | Epsin-3 | protein | 136 | 75% helix, 1% strand | P47160 |
| C | T-snare VTI1 | protein | 95 | 93% helix, 0% strand | Q04338 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 208 | 0.52 | 0.77 | 36 | empty |
| 2 | 142 | 0.46 | 0.77 | 17 | empty |
Interfaces
2 interfaces between chains.
- A–C · 734 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 732 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 3ONL · yeast Ent3_ENTH-Vti1p_Habc complex structure · the same entry in another collection · chain A against A, TM-score 1.00
- P47160 · AlphaFold monomer V2.0 prediction for epsin-3 (P47160) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q04338 · AlphaFold monomer V2.0 prediction for T-snare VTI1 (Q04338) · a predicted model of the same protein · chain C against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P47160
- Every structure of UniProt Q04338
- Elsewhere: RCSB PDB 3ONL · PDBe 3ONL · UniProt P47160 · UniProt Q04338
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