MolNFT v1 · #7402 · protein

Human BCL-2, isoform 1

1G5M · Protein (apoptosis regulator BCL-2 with putative flexible…: “Human BCL-2, isoform 1”. Solution nmr, 3 pockets (best druggability 0.44). MolNFT v1 #7402 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1G5M
Type: protein
Length: 164 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (apoptosis regulator BCL-2 with putative flexible loop replaced with a portion of…
UniProt: P10415, Q07817
Pockets: 3 · best druggability 0.44

Structure

solution nmr · 1 distinct chain · 63% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein (apoptosis regulator BCL-2 with putative flexible loop replaced with a portion of apoptosis regulator BCL-X protein)	protein	164	63% helix, 0% strand	P10415, Q07817

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	59	0.44	0.83	17	empty
2	93	0.40	0.77	15	empty
3	92	0.35	0.74	12	empty

Compared structures

1G5M · Human BCL-2, isoform 1 · the same entry in another collection · chain A against A, TM-score 1.00
P10415 · AlphaFold monomer V2.0 prediction for apoptosis regulator BCL-2 (P10415) · a predicted model of the same protein · chain A against A, TM-score 0.83
Q07817 · AlphaFold monomer V2.0 prediction for BCL-2-like protein 1 (Q07817) · a predicted model of the same protein · chain A against A, TM-score 0.83

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10415
Every structure of UniProt Q07817
Elsewhere: RCSB PDB 1G5M · PDBe 1G5M · UniProt P10415 · UniProt Q07817

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