MolNFT v1 · #73970 · protein

Crystal structure of curcuminoid synthase cus from oryza sativa

3OIT · OS07G0271500 protein: “Crystal structure of curcuminoid synthase cus from oryza sativa”. X-ray diffraction, 6 pockets (best druggability 0.78). MolNFT v1 #73970 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3OIT
Type: protein
Length: 739 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: OS07G0271500 protein
UniProt: Q8LIL0
Pockets: 6 · best druggability 0.78

Structure

x-ray diffraction · 2 distinct chains · 42% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	OS07G0271500 protein	protein	367	42% helix, 24% strand	Q8LIL0
B	OS07G0271500 protein	protein	372	43% helix, 24% strand	Q8LIL0

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	289	0.78	0.89	42	empty
2	302	0.76	0.88	52	empty
3	177	0.49	0.77	31	empty
4	160	0.48	0.78	29	empty
5	70	0.38	0.78	20	empty

Interfaces

1 interface between chains.

A–B · 2599 Å² buried · 55 hydrogen bonds · protein-protein

Compared structures

3OIT · Crystal structure of curcuminoid synthase CUS from Oryza sativa · the same entry in another collection · chain A against A, TM-score 1.00
Q8LIL0 · AlphaFold monomer V2.0 prediction for bisdemethoxycurcumin synthase (Q8LIL0) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8LIL0
Elsewhere: RCSB PDB 3OIT · PDBe 3OIT · UniProt Q8LIL0

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