Crystal structure of cytochrome P450CAM crystallized in the presence of a tethered substrate analog ADAC1-C8GLUETG-bio

Structure

x-ray diffraction · 1 distinct chain · 52% helix, 10% strand (DSSP).

Ligands and binding sites

• HEM · Protoporphyrin IX containing Fe · ligand · chains A
• A31 · N-{15-oxo-19-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-4,7,10-trioxa-14-azanonadec-1-yl}-N'-(8-{[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-ylcarbonyl]amino}octyl)pentanediamide · ligand · chains A
• K · Potassium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 3OIA · Crystal Structure of Cytochrome P450cam crystallized in the presence of a tethered… · the same entry in another collection · chain A against A, TM-score 1.00
• P00183 · AlphaFold monomer V2.0 prediction for camphor 5-monooxygenase (P00183) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P00183
• Elsewhere: RCSB PDB 3OIA · PDBe 3OIA · UniProt P00183