MolNFT v1 · #73944 · protein
Crystal structure of the human BACH2 poz domain, form I
3OHU · Transcription regulator protein BACH2: “Crystal structure of the human BACH2 poz domain, form I”. X-ray diffraction, 10 pockets (best druggability 0.71). MolNFT v1 #73944 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3OHU
- Type
- protein
- Length
- 713 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription regulator protein BACH2
- UniProt
- Q9BYV9
- Pockets
- 10 · best druggability 0.71
Structure
x-ray diffraction · 5 distinct chains · 44% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcription regulator protein BACH2 | protein | 125 | 41% helix, 19% strand | Q9BYV9 |
| B, D | Transcription regulator protein BACH2 | protein | 120 | 45% helix, 20% strand | Q9BYV9 |
| C | Transcription regulator protein BACH2 | protein | 113 | 46% helix, 21% strand | Q9BYV9 |
| E | Transcription regulator protein BACH2 | protein | 117 | 44% helix, 21% strand | Q9BYV9 |
| F | Transcription regulator protein BACH2 | protein | 118 | 44% helix, 21% strand | Q9BYV9 |
Pockets
10 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 682 | 0.71 | 0.78 | 63 | empty |
| 2 | 691 | 0.69 | 0.76 | 66 | empty |
| 3 | 76 | 0.57 | 0.88 | 23 | empty |
| 4 | 133 | 0.54 | 0.82 | 36 | empty |
| 5 | 155 | 0.53 | 0.81 | 37 | empty |
Interfaces
11 interfaces between chains.
- A–B · 2300 Ų buried · 29 hydrogen bonds · protein-protein
- D–E · 2103 Ų buried · 32 hydrogen bonds · protein-protein
- C–F · 1970 Ų buried · 25 hydrogen bonds · protein-protein
- A–D · 299 Ų buried · 0 hydrogen bonds · protein-protein
- A–F · 249 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 3OHU · Crystal structure of the human Bach2 POZ domain, form I · the same entry in another collection · chain F against F, TM-score 1.00
- Q9BYV9 · AlphaFold monomer V2.0 prediction for transcription regulator protein BACH2 (Q9BYV9) · a predicted model of the same protein · chain C against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BYV9
- Elsewhere: RCSB PDB 3OHU · PDBe 3OHU · UniProt Q9BYV9
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