MolNFT v1 · #73893 · protein
The crystal structure of human interferon lambda 1 complexed with its high affinity receptor in space group P21212
3OG4 · Interleukin-29: “The crystal structure of human interferon lambda 1 complexed with its high affinity receptor in space group…”. X-ray diffraction, 2 ligands (NAG, BMA), 3 pockets (best druggability 0.58). MolNFT v1 #73893 on…
- PDB
- 3OG4
- Type
- protein
- Length
- 337 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interleukin-29; Interleukin 28 receptor, alpha (interferon, lambda receptor)
- UniProt
- Q8IU54, Q5VTX7
- Ligands
- NAG, BMA
- Pockets
- 3 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interleukin-29 | protein | 140 | 74% helix, 0% strand | Q8IU54 |
| B | Interleukin 28 receptor, alpha (interferon, lambda receptor) | protein | 197 | 4% helix, 49% strand | Q5VTX7 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 3 copies · chains B
- BMA · beta-D-mannopyranose · sugar
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 265 | 0.58 | 0.78 | 40 | empty |
| 2 | 206 | 0.51 | 0.76 | 28 | empty |
| 3 | 54 | 0.32 | 0.77 | 10 | empty |
Interfaces
1 interface between chains.
- A–B · 827 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
- 3OG4 · The crystal structure of human interferon lambda 1 complexed with its high affinity… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8IU54 · AlphaFold monomer V2.0 prediction for interferon lambda-1 (Q8IU54) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IU54
- Every structure of UniProt Q5VTX7
- Elsewhere: RCSB PDB 3OG4 · PDBe 3OG4 · UniProt Q8IU54 · UniProt Q5VTX7
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