MolNFT v1 · #73867 · protein

Crystal structure of the L317I mutant of the chicken C-src tyrosine kinase domain

3OF0 · Proto-oncogene tyrosine-protein kinase src: “Crystal structure of the L317I mutant of the chicken C-src tyrosine kinase domain”. X-ray diffraction, 4 pockets (best druggability 0.74). MolNFT v1 #73867 on GenesisL1: 3D structure…

PDB: 3OF0
Type: protein
Length: 511 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Proto-oncogene tyrosine-protein kinase src
EC: 2.7.10.2
UniProt: P00523
Pockets: 4 · best druggability 0.74

Structure

x-ray diffraction · 2 distinct chains · 39% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Proto-oncogene tyrosine-protein kinase src (EC 2.7.10.2)	protein	260	40% helix, 18% strand	P00523
B	Proto-oncogene tyrosine-protein kinase src (EC 2.7.10.2)	protein	251	37% helix, 15% strand	P00523

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1062	0.74	0.77	100	empty
2	293	0.65	0.81	37	empty
3	153	0.39	0.73	30	empty
4	63	0.38	0.79	19	empty

Interfaces

1 interface between chains.

A–B · 386 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

3OF0 · crystal structure of the L317I mutant of the chicken c-Src tyrosine kinase domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00523
Elsewhere: RCSB PDB 3OF0 · PDBe 3OF0 · UniProt P00523

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