MolNFT v1 · #73825 · protein

Crystal structure of the N-terminal domain of human symplekin

3ODR: “Crystal structure of the N-terminal domain of human symplekin”. X-ray diffraction, 2 pockets (best druggability 0.56). MolNFT v1 #73825 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3ODR
Type: protein
Length: 317 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Symplekin
UniProt: Q92797
Pockets: 2 · best druggability 0.56

Structure

x-ray diffraction · 1 distinct chain · 77% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Symplekin	protein	317	77% helix, 0% strand	Q92797

Ligands and binding sites

EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	133	0.56	0.83	26	EDO
2	75	0.37	0.77	16	empty

Compared structures

3ODR · Crystal Structure of the N-terminal Domain of Human Symplekin · the same entry in another collection · chain A against A, TM-score 1.00
Q92797 · AlphaFold monomer V2.0 prediction for symplekin (Q92797) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q92797
Elsewhere: RCSB PDB 3ODR · PDBe 3ODR · UniProt Q92797

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