MolNFT v1 · #73787 · protein
Crystal structure of camp bound cgmp-dependent protein KINASE(92-227)
3OCP · PRKG1 protein: “Crystal structure of camp bound cgmp-dependent protein KINASE(92-227)”. X-ray diffraction, 1 ligand (CMP), 3 pockets (best druggability 0.66). MolNFT v1 #73787 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 3OCP
- Type
- protein
- Length
- 255 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- PRKG1 protein
- EC
- 2.7.11.12
- UniProt
- Q6P5T7
- Ligands
- CMP
- Pockets
- 3 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 29% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | PRKG1 protein (EC 2.7.11.12) | protein | 127 | 28% helix, 31% strand | Q6P5T7 |
| B | PRKG1 protein (EC 2.7.11.12) | protein | 128 | 30% helix, 30% strand | Q6P5T7 |
Ligands and binding sites
- CMP · Adenosine-3',5'-cyclic-monophosphate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 300 | 0.66 | 0.81 | 36 | CMP |
| 2 | 116 | 0.47 | 0.79 | 20 | CMP |
| 3 | 55 | 0.27 | 0.74 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 643 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 3OCP · Crystal structure of cAMP bound cGMP-dependent protein kinase(92-227) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6P5T7
- Elsewhere: RCSB PDB 3OCP · PDBe 3OCP · UniProt Q6P5T7
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