MolNFT v1 · #73700 · protein

Effector domain of influenza A/PR/8/34 NS1

3O9U · Nonstructural protein 1: “Effector domain of influenza A/PR/8/34 NS1”. X-ray diffraction, 11 pockets (best druggability 0.51). MolNFT v1 #73700 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3O9U
Type: protein
Length: 926 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nonstructural protein 1
UniProt: C9S2D8
Pockets: 11 · best druggability 0.51

Structure

x-ray diffraction · 2 distinct chains · 23% helix, 36% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, A, C, D, E, G, H	Nonstructural protein 1	protein	116	22% helix, 35% strand	C9S2D8
F	Nonstructural protein 1	protein	114	23% helix, 36% strand	C9S2D8

Pockets

11 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	297	0.51	0.74	25	empty
2	61	0.48	0.84	21	empty
3	64	0.46	0.82	21	empty
4	66	0.44	0.81	23	empty
5	96	0.44	0.79	21	empty

Interfaces

8 interfaces between chains.

F–H · 566 Å² buried · 6 hydrogen bonds · protein-protein
D–G · 535 Å² buried · 6 hydrogen bonds · protein-protein
B–E · 464 Å² buried · 6 hydrogen bonds · protein-protein
A–C · 453 Å² buried · 10 hydrogen bonds · protein-protein
B–A · 360 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

3O9U · Effector domain of influenza A/PR/8/34 NS1 · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt C9S2D8
Elsewhere: RCSB PDB 3O9U · PDBe 3O9U · UniProt C9S2D8

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