MolNFT v1 · #73564 · protein
FK1 domain mutant A19T of FKBP51, crystal form IV, in presence of dmso
3O5Q · Peptidyl-prolyl cis-trans isomerase FKBP5: “FK1 domain mutant A19T of FKBP51, crystal form IV, in presence of dmso”. X-ray diffraction, 1 pocket (best druggability 0.37). MolNFT v1 #73564 on GenesisL1: 3D structure, binding sites…
- PDB
- 3O5Q
- Type
- protein
- Length
- 128 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peptidyl-prolyl cis-trans isomerase FKBP5
- EC
- 5.2.1.8
- UniProt
- Q13451
- Pockets
- 1 · best druggability 0.37
Structure
x-ray diffraction · 1 distinct chain · 17% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Peptidyl-prolyl cis-trans isomerase FKBP5 (EC 5.2.1.8) | protein | 128 | 17% helix, 36% strand | Q13451 |
Ligands and binding sites
- DMS · Dimethyl sulfoxide · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 56 | 0.37 | 0.79 | 13 | DMS |
Compared structures
- 3O5Q · Fk1 domain mutant A19T of FKBP51, crystal form IV, in presence of DMSO · the same entry in another collection · chain A against A, TM-score 1.00
- Q13451 · AlphaFold monomer V2.0 prediction for peptidyl-prolyl cis-trans isomerase FKBP5 (Q13451) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13451
- Elsewhere: RCSB PDB 3O5Q · PDBe 3O5Q · UniProt Q13451
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