MolNFT v1 · #73553 · protein

FK1 domain of FKBP51, crystal form VI

3O5E · Peptidyl-prolyl cis-trans isomerase FKBP5: “FK1 domain of FKBP51, crystal form VI”. X-ray diffraction, 1 pocket (best druggability 0.32). MolNFT v1 #73553 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3O5E
Type: protein
Length: 128 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Peptidyl-prolyl cis-trans isomerase FKBP5
EC: 5.2.1.8
UniProt: Q13451
Pockets: 1 · best druggability 0.32

Structure

x-ray diffraction · 1 distinct chain · 15% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Peptidyl-prolyl cis-trans isomerase FKBP5 (EC 5.2.1.8)	protein	128	15% helix, 37% strand	Q13451

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	62	0.32	0.75	15	empty

Compared structures

3O5E · Fk1 domain of FKBP51, crystal form VI · the same entry in another collection · chain A against A, TM-score 1.00
Q13451 · AlphaFold monomer V2.0 prediction for peptidyl-prolyl cis-trans isomerase FKBP5 (Q13451) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13451
Elsewhere: RCSB PDB 3O5E · PDBe 3O5E · UniProt Q13451

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.