MolNFT v1 · #73251 · protein
The soluble domain structure of the zntb ZN2+ efflux system
3NWI · Zinc transport protein zntb: “The soluble domain structure of the zntb ZN2+ efflux system”. X-ray diffraction, 1 ligand (ZN), 14 pockets (best druggability 0.72). MolNFT v1 #73251 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3NWI
- Type
- protein
- Length
- 1,238 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Zinc transport protein zntb
- UniProt
- Q9EYX5
- Ligands
- ZN
- Pockets
- 14 · best druggability 0.72
Structure
x-ray diffraction · 4 distinct chains · 49% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Zinc transport protein zntb | protein | 245 | 48% helix, 17% strand | Q9EYX5 |
| B | Zinc transport protein zntb | protein | 247 | 49% helix, 17% strand | Q9EYX5 |
| C, D | Zinc transport protein zntb | protein | 249 | 47% helix, 17% strand | Q9EYX5 |
| E | Zinc transport protein zntb | protein | 248 | 49% helix, 17% strand | Q9EYX5 |
Ligands and binding sites
- ZN · Zinc ion · metal · 15 copies · chains A, B, C, D, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 282 | 0.72 | 0.86 | 33 | empty |
| 2 | 267 | 0.72 | 0.86 | 34 | ZN |
| 3 | 518 | 0.71 | 0.81 | 63 | empty |
| 4 | 291 | 0.71 | 0.85 | 31 | ZN |
| 5 | 309 | 0.71 | 0.84 | 33 | empty |
Interfaces
5 interfaces between chains.
- D–E · 817 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 813 Ų buried · 8 hydrogen bonds · protein-protein
- B–E · 781 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 779 Ų buried · 9 hydrogen bonds · protein-protein
- C–D · 777 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9EYX5
- Elsewhere: RCSB PDB 3NWI · PDBe 3NWI · UniProt Q9EYX5
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.