MolNFT v1 · #73245 · protein

Crystal structure of the pyrococcus furiosus smc protein hinge domain

3NWC: “Crystal structure of the pyrococcus furiosus smc protein hinge domain”. X-ray diffraction, 6 pockets (best druggability 0.53). MolNFT v1 #73245 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3NWC
Type: protein
Length: 357 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Smc protein
UniProt: Q877I1
Pockets: 6 · best druggability 0.53

Structure

x-ray diffraction · 2 distinct chains · 42% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Smc protein	protein	182	41% helix, 16% strand	Q877I1
B	Smc protein	protein	175	43% helix, 17% strand	Q877I1

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	236	0.53	0.77	24	empty
2	209	0.50	0.76	23	empty
3	171	0.47	0.76	27	empty
4	153	0.46	0.76	28	empty
5	111	0.44	0.78	20	empty

Interfaces

1 interface between chains.

A–B · 1598 Å² buried · 18 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 modified (engineered).

Compared structures

3NWC · Crystal Structure of the Pyrococcus furiosus SMC Protein Hinge Domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q877I1
Elsewhere: RCSB PDB 3NWC · PDBe 3NWC · UniProt Q877I1

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