MolNFT v1 · #73224 · protein

The soluble domain structure of the zntb ZN2+ efflux system

3NVO · Zinc transport protein zntb: “The soluble domain structure of the zntb ZN2+ efflux system”. X-ray diffraction, 2 ligands (ZN, SO4), 3 pockets (best druggability 0.77). MolNFT v1 #73224 on GenesisL1: 3D structure, binding sites and…

PDB: 3NVO
Type: protein
Length: 497 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Zinc transport protein zntb
UniProt: Q9EYX5
Ligands: ZN, SO4
Pockets: 3 · best druggability 0.77

Structure

x-ray diffraction · 2 distinct chains · 50% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Zinc transport protein zntb	protein	250	50% helix, 17% strand	Q9EYX5
B	Zinc transport protein zntb	protein	247	50% helix, 16% strand	Q9EYX5

Ligands and binding sites

ZN · Zinc ion · metal · 8 copies · chains A, B
SO4 · Sulfate ion · ion · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	956	0.77	0.79	119	SO4, ZN
2	159	0.48	0.77	24	empty
3	55	0.29	0.74	14	empty

Interfaces

1 interface between chains.

A–B · 849 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

3NVO · The Soluble Domain Structure of the ZntB Zn2+ Efflux System · the same entry in another collection · chain A against A, TM-score 1.00
Q9EYX5 · AlphaFold monomer V2.0 prediction for zinc transport protein zntb (Q9EYX5) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9EYX5
Elsewhere: RCSB PDB 3NVO · PDBe 3NVO · UniProt Q9EYX5

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