MolNFT v1 · #73130 · protein

The multi-copper oxidase cueo with six met to ser mutations (M358S, M361S,M362S,M364S,M366S,M368S)

3NSY · Blue copper oxidase cueo: “The multi-copper oxidase cueo with six met to ser mutations (M358S, M361S,M362S,M364S,M366S,M368S)”. X-ray diffraction, 2 ligands (C2O, CU), 4 pockets (best druggability 0.43). MolNFT v1 #73130 on…

PDB: 3NSY
Type: protein
Length: 465 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Blue copper oxidase cueo
UniProt: P36649
Ligands: C2O, CU
Pockets: 4 · best druggability 0.43

Structure

x-ray diffraction · 1 distinct chain · 11% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Blue copper oxidase cueo	protein	465	11% helix, 42% strand	P36649

Ligands and binding sites

C2O · Cu-O-Cu linkage · ligand · chains A
CU · Copper (II) ion · metal · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	115	0.43	0.77	22	empty
2	52	0.42	0.83	20	empty
3	67	0.41	0.80	20	empty
4	82	0.35	0.75	19	empty

Compared structures

3NSY · The multi-copper oxidase CueO with six Met to Ser mutations… · the same entry in another collection · chain A against A, TM-score 1.00
P36649 · AlphaFold monomer V2.0 prediction for blue copper oxidase cueo (P36649) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P36649
Elsewhere: RCSB PDB 3NSY · PDBe 3NSY · UniProt P36649

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