MolNFT v1 · #72953 · protein

BEF3 activated drrb receiver domain

3NNS · DNA binding response regulator B: “BEF3 activated drrb receiver domain”. X-ray diffraction, 2 ligands (BEF, MG), 2 pockets (best druggability 0.60). MolNFT v1 #72953 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3NNS
Type: protein
Length: 234 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA binding response regulator B
UniProt: Q9WXY0
Ligands: BEF, MG
Pockets: 2 · best druggability 0.60

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	DNA binding response regulator B	protein	117	41% helix, 22% strand	Q9WXY0

Ligands and binding sites

BEF · Beryllium trifluoride ion · ligand · 2 copies · chains A, B
MG · Magnesium ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	290	0.60	0.78	26	empty
2	55	0.43	0.82	13	empty

Interfaces

1 interface between chains.

A–B · 827 Å² buried · 17 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 modified (engineered).

Compared structures

3NNS · BeF3 Activated DrrB Receiver Domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9WXY0
Elsewhere: RCSB PDB 3NNS · PDBe 3NNS · UniProt Q9WXY0

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.