MolNFT v1 · #72944 · protein + RNA
Crystal structure of the CUGBP1 RRM1 with guuguuuuguuu RNA
3NNH · Cugbp elav-like family member 1: “Crystal structure of the CUGBP1 RRM1 with guuguuuuguuu RNA”. X-ray diffraction, 3 pockets (best druggability 0.71). MolNFT v1 #72944 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3NNH
- Type
- protein + RNA
- Length
- 364 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cugbp elav-like family member 1; RNA (5'-R(*GP*UP*UP*GP*UP*UP*UP*UP*GP*UP*UP*U)-3')
- UniProt
- Q92879
- Pockets
- 3 · best druggability 0.71
Structure
x-ray diffraction · 5 distinct chains · 23% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Cugbp elav-like family member 1 | protein | 86 | 22% helix, 34% strand | Q92879 |
| C | Cugbp elav-like family member 1 | protein | 85 | 22% helix, 34% strand | Q92879 |
| E | RNA (5'-R(*GP*UP*UP*GP*UP*UP*UP*UP*GP*UP*UP*U)-3') | rna | 10 | — | — |
| D | Cugbp elav-like family member 1 | protein | 87 | 25% helix, 32% strand | Q92879 |
| F | RNA (5'-R(*GP*UP*UP*GP*UP*UP*UP*UP*GP*UP*UP*U)-3') | rna | 10 | — | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 719 | 0.71 | 0.78 | 51 | empty |
| 2 | 128 | 0.48 | 0.79 | 26 | empty |
| 3 | 54 | 0.32 | 0.77 | 12 | empty |
Interfaces
9 interfaces between chains.
- A–E · 712 Ų buried · 16 hydrogen bonds · protein-nucleic
- D–F · 572 Ų buried · 13 hydrogen bonds · protein-nucleic
- C–E · 504 Ų buried · 10 hydrogen bonds · protein-nucleic
- B–F · 425 Ų buried · 13 hydrogen bonds · protein-nucleic
- C–B · 248 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 3NNH · Crystal Structure of the CUGBP1 RRM1 with GUUGUUUUGUUU RNA · the same entry in another collection · chain F against F, TM-score 1.00
- Q92879 · AlphaFold monomer V2.0 prediction for cugbp elav-like family member 1 (Q92879) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92879
- Elsewhere: RCSB PDB 3NNH · PDBe 3NNH · UniProt Q92879
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.