MolNFT v1 · #72925 · protein

Crystal structure of armadillo repeats domain of apc

3NMW · Apc variant protein: “Crystal structure of armadillo repeats domain of apc”. X-ray diffraction, 1 ligand (SO4), 4 pockets (best druggability 0.73). MolNFT v1 #72925 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3NMW
Type: protein
Length: 662 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Apc variant protein
UniProt: Q4LE70
Ligands: SO4
Pockets: 4 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 75% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Apc variant protein	protein	331	75% helix, 0% strand	Q4LE70

Ligands and binding sites

SO4 · Sulfate ion · ion · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	492	0.73	0.82	59	SO4
2	361	0.55	0.74	29	empty
3	189	0.51	0.77	25	empty
4	62	0.29	0.75	15	empty

Interfaces

1 interface between chains.

A–B · 725 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 28 modified (engineered).

Compared structures

3NMW · Crystal structure of armadillo repeats domain of APC · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q4LE70
Elsewhere: RCSB PDB 3NMW · PDBe 3NMW · UniProt Q4LE70

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