MolNFT v1 · #72917 · protein

Crystal structure of an engineered monomeric clc-EC1 cl-/H+ transporter

3NMO · H(+)/CL(-) exchange transporter clca: “Crystal structure of an engineered monomeric clc-EC1 cl-/H+ transporter”. X-ray diffraction, 1 ligand (CL), 3 pockets (best druggability 0.70). MolNFT v1 #72917 on GenesisL1: 3D structure…

PDB: 3NMO
Type: protein
Length: 439 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: H(+)/CL(-) exchange transporter clca
UniProt: P37019
Ligands: CL
Pockets: 3 · best druggability 0.70

Structure

x-ray diffraction · 1 distinct chain · 75% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	H(+)/CL(-) exchange transporter clca	protein	439	75% helix, 1% strand	P37019

Ligands and binding sites

CL · Chloride ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	322	0.70	0.83	27	empty
2	338	0.61	0.78	38	empty
3	72	0.29	0.73	15	empty

Compared structures

3NMO · Crystal structure of an engineered monomeric CLC-ec1 Cl-/H+ transporter · the same entry in another collection · chain A against A, TM-score 1.00
P37019 · AlphaFold monomer V2.0 prediction for H(+)/CL(-) exchange transporter clca (P37019) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P37019
Elsewhere: RCSB PDB 3NMO · PDBe 3NMO · UniProt P37019

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