MolNFT v1 · #72678 · protein

Crystal structure of the conserved central domain of yeast SPN1/IWS1

3NFQ · Transcription factor IWS1: “Crystal structure of the conserved central domain of yeast SPN1/IWS1”. X-ray diffraction, 1 pocket (best druggability 0.75). MolNFT v1 #72678 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3NFQ
Type: protein
Length: 290 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcription factor IWS1
UniProt: Q06505
Pockets: 1 · best druggability 0.75

Structure

x-ray diffraction · 2 distinct chains · 74% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcription factor IWS1	protein	147	73% helix, 0% strand	Q06505
B	Transcription factor IWS1	protein	143	76% helix, 0% strand	Q06505

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1075	0.75	0.78	95	empty

Interfaces

1 interface between chains.

A–B · 355 Å² buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 modified (engineered).

Compared structures

3NFQ · Crystal structure of the conserved central domain of yeast Spn1/Iws1 · the same entry in another collection · chain A against A, TM-score 1.00
Q06505 · AlphaFold monomer V2.0 prediction for transcription factor SPN1 (Q06505) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q06505
Elsewhere: RCSB PDB 3NFQ · PDBe 3NFQ · UniProt Q06505

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