MolNFT v1 · #72637 · protein
Q28E mutant of hera RNA helicase N-terminal domain - perfectly twinned hexagonal form
3NEJ · Heat resistant RNA dependent ATPase: “Q28E mutant of hera RNA helicase N-terminal domain - perfectly twinned hexagonal form”. X-ray diffraction, 2 pockets (best druggability 0.73). MolNFT v1 #72637 on GenesisL1: 3D structure…
- PDB
- 3NEJ
- Type
- protein
- Length
- 406 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heat resistant RNA dependent ATPase
- UniProt
- Q72GF3
- Pockets
- 2 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heat resistant RNA dependent ATPase | protein | 201 | 35% helix, 11% strand | Q72GF3 |
| B | Heat resistant RNA dependent ATPase | protein | 205 | 36% helix, 14% strand | Q72GF3 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1165 | 0.73 | 0.76 | 102 | empty |
| 2 | 58 | 0.51 | 0.86 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 270 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 3NEJ · Q28E mutant of Hera RNA helicase N-terminal domain - perfectly twinned hexagonal form · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q72GF3
- Elsewhere: RCSB PDB 3NEJ · PDBe 3NEJ · UniProt Q72GF3
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