MolNFT v1 · #72381 · protein + DNA
Crystal structure of human mitochondrial mterf in complex with a 15- mer DNA encompassing the TRNALEU(UUR) binding sequence
3N6S · Transcription termination factor, mitochondrial: “Crystal structure of human mitochondrial mterf in complex with a 15- mer DNA encompassing the TRNALEU(UUR)…”. X-ray diffraction, 1 pocket (best druggability 0.69). MolNFT v1 #72381…
- PDB
- 3N6S
- Type
- protein + DNA
- Length
- 374 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription termination factor, mitochondrial; DNA…
- UniProt
- Q99551
- Pockets
- 1 · best druggability 0.69
Structure
x-ray diffraction · 3 distinct chains · 69% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcription termination factor, mitochondrial | protein | 344 | 69% helix, 0% strand | Q99551 |
| B | DNA (5'-D(*AP*TP*GP*GP*CP*AP*GP*AP*GP*CP*CP*CP*GP*GP*T)- 3') | dna | 15 | — | — |
| C | DNA (5'-D(*TP*AP*CP*CP*GP*GP*GP*CP*TP*CP*TP*GP*CP*CP*A)- 3') | dna | 15 | — | — |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 541 | 0.69 | 0.79 | 51 | empty |
Interfaces
3 interfaces between chains.
- B–C · 661 Ų buried · 46 hydrogen bonds · nucleic-nucleic
- A–C · 470 Ų buried · 12 hydrogen bonds · protein-nucleic
- A–B · 340 Ų buried · 5 hydrogen bonds · protein-nucleic
Compared structures
- 3N6S · Crystal structure of human mitochondrial mTERF in complex with a 15-mer DNA encompassing… · the same entry in another collection · chain A against A, TM-score 1.00
- Q99551 · AlphaFold monomer V2.0 prediction for transcription termination factor 1, mitochondrial… · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99551
- Elsewhere: RCSB PDB 3N6S · PDBe 3N6S · UniProt Q99551
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