MolNFT v1 · #7237 · protein
Dsbc mutant C101S
1G0T · THIOL:DISULFIDE interchange protein dsbc: “Dsbc mutant C101S”. X-ray diffraction, 1 pocket (best druggability 0.38). MolNFT v1 #7237 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1G0T
- Type
- protein
- Length
- 431 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- THIOL:DISULFIDE interchange protein dsbc
- EC
- 5.3.4.1
- UniProt
- P21892
- Pockets
- 1 · best druggability 0.38
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | THIOL:DISULFIDE interchange protein dsbc (EC 5.3.4.1) | protein | 215 | 40% helix, 23% strand | P21892 |
| B | THIOL:DISULFIDE interchange protein dsbc (EC 5.3.4.1) | protein | 216 | 40% helix, 23% strand | P21892 |
Ligands and binding sites
- PEG · Di(hydroxyethyl)ether · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 86 | 0.38 | 0.76 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 888 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 1G0T · Dsbc mutant C101S · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21892
- Elsewhere: RCSB PDB 1G0T · PDBe 1G0T · UniProt P21892
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