MolNFT v1 · #7206 · protein

Crystal structure of saccharomyces cerevisiae ubiquitin conjugating enzyme 1

1FZY · Ubiquitin-conjugating enzyme E2-24 kda: “Crystal structure of saccharomyces cerevisiae ubiquitin conjugating enzyme 1”. X-ray diffraction, 2 pockets (best druggability 0.55). MolNFT v1 #7206 on GenesisL1: 3D structure, binding sites…

PDB: 1FZY
Type: protein
Length: 298 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ubiquitin-conjugating enzyme E2-24 kda
EC: 6.3.2.19
UniProt: P21734
Pockets: 2 · best druggability 0.55

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Ubiquitin-conjugating enzyme E2-24 kda (EC 6.3.2.19)	protein	149	38% helix, 17% strand	P21734

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	307	0.55	0.75	28	empty
2	135	0.44	0.76	20	empty

Interfaces

1 interface between chains.

A–B · 394 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

1FZY · Crystal structure of saccharomyces cerevisiae ubiquitin conjugating enzyme 1 · the same entry in another collection · chain A against A, TM-score 1.00
P21734 · AlphaFold monomer V2.0 prediction for ubiquitin-conjugating enzyme E2 1 (P21734) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P21734
Elsewhere: RCSB PDB 1FZY · PDBe 1FZY · UniProt P21734

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